Pair Name	Eugenol, Cisplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Phosphorylation	CDH13	hsa1012
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Phosphorylation	RELA	hsa5970
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	MDA-MB-468	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0419
	BT-20	Invasive breast carcinoma	Homo sapiens (Human)	CVCL_0178
In Vivo Model	Breast cancer xenografts were created 4-6 week female nude mice by subcutaneous injection of the MDA-MB-231 cells (5×10⁶) into the right leg of each mouse.
Result	These results provide strong preclinical justification for combining cisplatin with eugenol as therapeutic approach for triple-negative breast cancers through targeting the resistant ALDH-positive cells and inhibiting the NF-κB pathway.

Pair Name	Eugenol, Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Expression	CASP9	hsa842
	Up-regulation	Expression	CYCS	hsa54205
	Down-regulation	Expression	IL1B	hsa3553
	Down-regulation	Expression	PTGS2	hsa5743
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
Result	Eugenol showed antiproliferative and cytotoxic effects via apoptosis and also synergism with cisplatin and ionizing radiation in the human cervical cancer cell line.